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Expertise
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Work
Work
With J.A. Boylan, C. Hummel, S. Benoit, J. Garcia-Lara, J. Treglown, and F.C. Gherardini, “Identification of a Coenzyme A Disulfide Reductase from Borrelia Burgdorferi,” Molecular Microbiology 59:475-486, 2006
With C.S. Hummel and K.M. Lancaster, “Determination of coenzyme A levels in Pyrococcus furiosus and other Archaea: implications for a general role for coenzyme A in thermophiles,” FEMS Microbiological Letters 252:229-234, 2005
With D.R. Harris, D. E. Ward, J. T. Feasel, K.M. Lancaster, R.D. Murphy, and T.C. Mallet, “Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii: Implications for the disulfide metabolism of anaerobic hyperthermophiles,” FEBS Journal 272:1189-1200, 2005
With C. Donnelly, M. Mullendrone, J. van der Oost, and W. de Vos, "The NADH Oxidase from Pyrococcus furiosus: Implications for the Protection of Anaerobic Hyperthermophiles Against Oxidative Stress," European Journal of Biochemistry, 2001
With J. Yeh, J. Luba and A. Claiborne, "Analysis of the Kinetic and Redox Properties of the NADH Peroxidase R303M Mutant: Correlation with the Crystal Structure," Biochemistry, 39, 10353-10364, 2000
With A. Claiborne, J. Yeh, T. Mallet, J. Luba, V. Charrier, and D. Parsonage, "Protein Sulfenic Acids: Diverse Roles for an Unlikely Player in Enzyme Catalysis and Redox Regulation," Biochemistry, 38, 15407-15416, 1999
With D.E. Ward, J. van der Oost, Q. She, and R. Garrett, "Sequence Analysis and Overexpression of Putative NADH Oxidases from the Hyperthermophilic Archaeons Sulfolobus Solfataricus and Pyrrococcus Horikoshii," in Flavins and Flavoproteins 1999 (S. Ghisla, P. Kroneck, P. Macheroux, and H. Sund, eds., Rudolf Weber, 1999)
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Education
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Awards & Honors
Awards & Honors
American Chemical Society, Petroleum Research Fund, (PI) $55,000 grant for “Mechanisms of Sulfur Reduction by Sulfur/Polysulfide Reductase,” 2007-2010
U.S. Department of Energy, Genomes to Life Initiative, (CoPI) “Integrated Genome-Based Studies of Shewanella Ecophysiology, 2007-
Pomona College, Wig Distinguished Professorship Award for Excellence in Teaching, 2005
Cottrell College Science Award, Research Corporation; $40,000, (PI) “A mechanistic study of thermophilic NADH oxidases from Pyrococcus: Are thermophilic and mesophilic catalytic structures different?” 2000-02; and $39,036, (PI) “Enzymatic mechanisms of control of internal redox environment in hyperthermophiles, 2003-05
Howard Hughes Medical Institute, Undergraduate Science Education Program (contributor), 2003-06
National Science Foundation, Major Research Grant Instrumentation Grant $235,780, (CoPI) “Genomic and Genetic Analysis Research in Molecular Biology at Pomona College, 2003-06
Salisbury University, Distinguished Faculty Award, 1999; National Institutes of Health, National Research Service Award, 1994-1996; The Johns Hopkins University, Harry D. Kruse Award in Nutrition and Public Health, 1992