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Maria Cristina (Tina) Negritto

Director of Molecular Biology

Contact Information

R. C. Seaver Biology Building, Room 221
175 W Sixth Street
Claremont, CA 91711
909-607-9632
tina.negritto@pomona.edu

Education

Ph.D., Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA
Licenciatura in Biology, School of Hard Sciences, University of Buenos Aires, Buenos Aires, Argentina

Professional Experience

Director of Molecular Biology, Pomona College
Lecturer in Chemistry, Pomona College

Courses

Molecular Biology 185: Biochemistry and Molecular Biology of DNA Repair
Molecular Biology 187: Human Diseases with Defective Genome Maintenance Mechanisms
Molecular Biology 188: Molecular Biology Laboratory

Research Interests

The study of genome maintenance mechanisms, in particular DNA recombination between short homologous sequences and how it can affect genome instability.

Selected Publications

Negritto, M.C, J. Qiu, D.O. Ratay, B. Shen, and A.M. Bailis. 2001. Novel function of Rad27 (FEN-1) in restricting short-sequence recombination. Mol. Cell. Biol. 21: 2349-2358. [abstract | full text | pdf]

Maines, S., M.C. Negritto, X. Wu, G.M. Manthey, and A.M. Bailis. 1998. Novel mutations in the RAD3 and SSL1 genes perturb genome stability. Genetics 150: 963-976. [abstract | full text | pdf]

Negritto, M.C., X. Wu, T. Kuo, S. Chu, and A.M. Bailis. 1997. Influence of DNA sequence identity on efficiency of targeted gene replacement. Mol. Cell. Biol. 17: 278-286. [abstract | pdf]

Bailis, A.M., S. Maines, and M.C. Negritto. 1995. The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 3998-4008. [abstract | pdf]